1
Gholamreza Sheikhnehjad, Mina Patel Sooch, Neal Goodwin, David Olson: Methods and compositions for the inhibition of gene expression. ProNAI Therapeutics, Honigman Miller, Jonathan P O Brien, Kelly T Murphy, March 3, 2009: US07498315 (4 worldwide citation)


The present invention relates to methods and compositions for the inhibition of gene expression. In particular, the present invention provides oligonucleotide-based therapeutics for the inhibition of oncogenes involved in cancers.


2
Gholamreza Sheikhnejad, Neal Goodwin, David Olson: Methods and compositions for cancer therapy. ProNAI Therapeutics, Honigman Miller Schwartz and Cohn, Kelly T Murphy, Jonathan P O Brien, October 5, 2010: US07807647 (4 worldwide citation)


The present invention relates to methods and compositions for the inhibition of gene expression. In particular, the present invention provides oligonucleotide-based therapeutics for the inhibition of oncogenes involved in cancers.


3
Goodwin Neal Clifford, Endert Gerold, Herzog Natalie, Kerwitz Yvonne, Panzner Steffen, Rodrigueza Wendi: Amphoteric liposome formulation. Pronai Therapeutics, Goodwin Neal Clifford, Endert Gerold, Herzog Natalie, Kerwitz Yvonne, Panzner Steffen, Rodrigueza Wendi, O BRIEN Jonathan P, June 7, 2007: WO/2007/064857 (4 worldwide citation)


The invention relates to compositions and methods to inhibit gene expression. In particular, the invention provides DNAi oligonucleotides sequestered by amphoteric liposomes for the treatment of cancer.


4

5
Sheikhnehjad Gholamreza, Sooch Mina Patel, Goodwin Neal, Olson David: Methods and compositions for the inhibition of gene expression. Pronai Therapeutics, Sheikhnehjad Gholamreza, Sooch Mina Patel, Goodwin Neal, Olson David, O BRIEN Jonathan P, December 15, 2005: WO/2005/118824 (3 worldwide citation)


The present invention relates to methods and compositions for the inhibition of gene expression. In particular, the present invention provides oligonucleotide-based therapeutics for the inhibition of oncogenes involved in cancers.


6
Goodwin Neal Clifford: Locked nucleic acid oligonucleotides. Pronai Therapeutics, Goodwin Neal Clifford, O BRIEN Jonathan P, June 7, 2007: WO/2007/064853 (2 worldwide citation)


The present invention provides oligonucleotides and compositions thereof for the treatment and prevention of cancer, wherein said oligonucleotides comprise locked nucleic acid nucleotides.


7
Goodwin Neal Clifford, Mc, Govren James Patrick: Cancer therapies and pharmaceutical compositions used therein. Pronai Therapeutics, Goodwin Neal Clifford, Mc, Govren James Patrick, O BRIEN Jonathan P, June 7, 2007: WO/2007/064945 (2 worldwide citation)


The invention relates to compositions and methods to inhibit gene expression. In particular, the invention provides co-therapies comprising oligonucleotides plus other therapies to treat cancer.


8
Rodrigueza Wendi, Goodwin Neal Clifford: Dnai amphoteric liposome formulation. Pronai Therapeutics, Rodrigueza Wendi, Goodwin Neal Clifford, MURPHY Kelly T, April 23, 2009: WO/2009/051712 (2 worldwide citation)


The invention provides compositions comprising DNAi-oligonucleotides sequestered in stable, size-selected amphoteric liposomes for treating cancer. The invention also provides methods of preparing the compositions.


9
Gholamreza Sheikhnehjad, Mina Patel Sooch, Neal Clifford Goodwin, David Olson: Methods and compositions for the inhibition of gene expression. ProNAi Therapeutics, Honigman Miller Schwartz & Cohn, Kelly T Murphy, Jonathan P O Brien, August 26, 2014: US08815599 (1 worldwide citation)


The present invention relates to methods and compositions for the inhibition of gene expression. In particular, the present invention provides oligonucleotide-based therapeutics for the inhibition of oncogenes involved in cancers.


10
Neal Clifford Goodwin, Gerold Endert, Natalie Herzog, Yvonne Kerwitz, Steffen Panzner, Wendi Rodrigueza: Amphoteric liposome formulation. ProNAi Therapeutics, Novosom, Honigman Miller Schwartz and Cohn, Jonathan P O Brien, Kelly T Murphy, February 5, 2013: US08367628 (1 worldwide citation)


The invention relates to compositions and methods to inhibit gene expression. In particular, the invention provides DNAi oligonucleotides sequestered by amphoteric liposomes for the treatment of cancer.



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