1
Regina Reszka, Gerd Berger, Uwe Pohlen, Marion Jung: Anti-tumoral therapy agent containing a contrast agent. Max Delbrück Centrum für Molekulare Medizin, Norris McLaughlin & Marcus P A, March 27, 2001: US06207133 (12 worldwide citation)


The invention relates to a new anti-tumoral therapy agent based on liposome-encapsulated cytostatic agents and/or the metabolites thereof. The invention can be used in the pharmaceutical industry and in medicine. The aim of the invention is to build up drug targeting to combat cancer through suitabl ...


2
Martin Brandl, Dieter Bachmann, Regine Reszka, Markus Drechsler: Unilamellar liposomal preparations with high active substance content. Martin Brandl, Max Delbrück Centrum für Molekulare Medizin, Norris McLaughlin & Marcus, June 4, 2002: US06399094 (8 worldwide citation)


A liposomal vesicular preparation with good encapsulation efficiency for active ingredients, based on homogeneous unilamellar liposomal vesicular lipids, has a substantially tightly packed vesicular structure and forms carriers of active ingredients. At least 20% by weight relative to the total weig ...


3
Izsvak Zsuzsanna, Ivics Zoltan, Fröhlich Janine, Grabundzija Ivana, Mates Lajos, Hübner Norbert, Hamra F Kent: Max Delbrück Centrum Für Molekulare Medizin, Izsvak Zsuzsanna, Ivics Zoltan, Fröhlich Janine, Grabundzija Ivana, Mates Lajos, Hübner Norbert, Hamra F Kent, VOSSIUS Siebertstrasse 4 81675 München, June 11, 2009: WO/2009/071334 (5 worldwide citation)


The present invention relates to a method for generating mutations in spermatogonial stem cells comprising introducing at least one transposon into the spermatogonial stem cells. The invention further relates to cells obtainable by the method of the invention, a method for linking physiological data ...


4
Gerd Wallukat, Volker Homuth, Friedrich Luft: receptor and their uses, Peptides of the AT. Max Delbrück Centrum für Molekulare Medizin, Joyce V Natzmer, Pequignot Myers, June 29, 2010: US07745139 (3 worldwide citation)


Disclosed are peptides of the AT1 receptor and their use for eliminating specifically binding, cell-physiologically active, pathological antibodies in preeclampsia and malign hypertension. The peptides may, for example, be used for the diagnosis of preeclampsia. Peptides having the sequence AFHYESQ ...


5
Miskey Csaba, Ivics Zoltan: Reconstructed human mariner transposon capable of stable gene transfer into chromosomes in vertebrates. Max Delbrück Centrum Für Molekulare Medizin, Miskey Csaba, Ivics Zoltan, GRAF VON STOSCH Andreas, October 19, 2006: WO/2006/108525 (3 worldwide citation)


The present invention refers to a gene transfer system for stably introducing nucleic acid(s) into the DNA of a cell by using a member of the human mariner transposases. The invention further refers to this transposase and to transposons used in the inventive gene transfer system, comprising a nucle ...


6
Izsvak Zsuzsanna, Ivics Zoltan, Mates Lajos, Manoj Namitha, Judis Carmen Anisia, Katzer Andrea: Hyperactive variants of the transposase protein of the transposon system sleeping beauty. Max Delbrück Centrum Für Molekulare Medizin, Izsvak Zsuzsanna, Ivics Zoltan, Mates Lajos, Manoj Namitha, Judis Carmen Anisia, Katzer Andrea, GRAF VON STOSCH Andreas, January 8, 2009: WO/2009/003671 (3 worldwide citation)


The present invention refers to hyperactive variants of a transposase of the transposon system Sleeping Beauty (SB). The invention further refers to corresponding nucleic acids producing these variants, to a gene transfer system for stably introducing nucleic acid(s) into the DNA of a cell by using ...


7
Lewin Gary, Shin Jung Bum: Pharmaceutical composition comprising calcium channel blockers for the treatment of pain. Max Delbrück Centrum Für Molekulare Medizin, Lewin Gary, Shin Jung Bum, VOSSIUS Siebertstrasse 4 81675 Münich, December 31, 2003: WO/2004/000311 (3 worldwide citation)


The invention relates to an agent for the medicamentous treatment of acute and chronic pain, in particular of allodynia and hyperalgesia. Fields of application of the invention are medicine and the pharmaceutical industry. A new pharmaceutical composition for the treatment of acute and/or chronic pa ...


8
Uwe Karsten, Franz Georg Hanisch, Hans Paulsen: Tumor vaccines for MUC1-positive carcinomas. Max Delbrück Centrum für Molekulare Medizin, Duane A Stewart III, Buchanan Ingersoll & Rooney PC, March 11, 2008: US07342094 (2 worldwide citation)


Tumor vaccines for the use against MUC1 positive carcinomas are presented. A tumor vaccine containing synthetic peptides comprising sequences of the human epithelial mucin MUC1 containing the immunodominat region PDTRPAP which is glycosylated at the threonine. Preferred glycosylation of the immunodo ...


9
Wallukat Gerd: (De) Bestimmung agonistischer autoantikörper, (En) Identification of agonistic autoantibodies. Max Delbrück Centrum Für Molekulare Medizin, Wallukat Gerd, RASCH Dorit, June 17, 2004: WO/2004/051280 (2 worldwide citation)


(EN) The invention relates to a method for detecting disease-associated autoantibodies, which recognize extracellular structures of G protein-coupled receptors, and to the use of peptides, which comprise these loops or fragments thereof, for treating autoimmune diseases.(DE) Die Erfindung betrifft e ...


10
Wallukat Gerd, Harrer Thomas, Michael Dandel: Autoantibody binding peptides and their use for the treatment of vascular diseases. Max Delbrück Centrum Für Molekulare Medizin, Deutsches Herzzentrum Berlin, Wallukat Gerd, Harrer Thomas, Michael Dandel, BOECKH Tobias, December 18, 2008: WO/2008/151847 (2 worldwide citation)


The application relates to peptides and nucleic acid molecules encoding peptides which interact with autoantibodies associated with coronary arterial occlusion, angina pectoris, pulmonary hypertension, occlusion of peripheral arterial vessels, Raynaud syndrome and scleroderma, to the peptides themse ...



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