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Wanker Erich, Lalowski Maciej, Stelzl Ulrich, Stroedicke Martin, Haenig Christian, Worm Uwe, Goehler Heike: Method for the identification of protein-protein interactions in disease related protein networks. Max Delbrueck Centrum, July 5, 2006: EP1677113-A1 (9 worldwide citation)


The present invention relates to a method for identification of a protein-protein interaction of protein interaction partners in a disease-related network of proteins comprising the steps of (a) identifying nucleic acid molecules by at least partial 5'sequencing and, optionally, additionally adding ...


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Blankenstein Thomas, Uckert Wolfgang, Kieback Elisa, Charo Jehad: Epitope-tag for surface-expressed t-cell receptor proteins, uses thereof and method of selecting host cells expressing them. Max Delbrueck Centrum, January 16, 2008: EP1878744-A1 (5 worldwide citation)


The present invention relates to a method for selecting a host cell population expressing a functional fusion protein comprising at least one epitope-providing amino acid sequence (epitope-tag) and the amino acid sequence of a protein that is expressed on the surface of said host cell. Preferably, t ...


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Human-derived T cell receptors. Max Delbrueck Centrum, May 19, 2010: EP2186825-A1 (4 worldwide citation)


The invention pertains to a human-derived T cell receptor (mhTCR) that, compared to the human wild-type T cell receptor (wtTCR), bears mutations at certain sites of the constant TCR beta region 2 (C2) or the constant TCR beta region 1 (C1) and the constant TCR alpha region (C+-). The presence of the ...


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Wallukat Gerd, Kunze Rudolf, Herrmann Martin, Voll Reinhard, Juenemann Anselm, Schloetzer Ursula: Peptides against autoantibodies associated with glaucoma and use of these peptides. Max Delbrueck Centrum, Univ Friedrich Alexander Er, Fresenius Medical Care de, September 12, 2007: EP1832600-A1 (3 worldwide citation)


The invention relates to nucleic acid molecules encoding peptides which interact with autoantibodies associated with glaucoma, to the peptides themselves, to a pharmaceutical composition comprising said nucleic acid molecules and peptides, and to the use of said peptides - especially in apheresis - ...


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Dolores Schendel, Susanne Wilde, Thomas Blankenstein: Generation of antigen specific T cells. Helmholtz Zentrum Muenchen Deutsches Forschungzentrum fuer Gesundheit und Umwelt, Max Delbrueck Centrum fuer Molekulare Medizin, Jenkins Wilson Taylor & Hunt P A, July 16, 2013: US08486694 (2 worldwide citation)


The present invention is directed to a method of generating antigen specific T cells. Furthermore, the invention is directed to antigen specific T cells, isolated transgenic TCR's, pharmaceutical compositions containing same and their use in adoptive cell therapy. This invention in particular pertai ...


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Gotthardt Michael, Radke Michael: Inducible site-directed mutagenesis through conditional gene rescue. Max Delbrueck Centrum, October 13, 2004: EP1466974-A1 (1 worldwide citation)


The present invention relates to a conditionally inducible site-directed mutant cell, comprising a mutated allele of a gene; wherein said allele comprises a mutation that was introduced by using a suitable mutagenesis technique, a rescue allele of said mutated gene that can be conditionally inactiva ...


10
Schmetzer Oliver, Pezzutto Antonio: Peptides regulating the surface expression of the t cell receptor. Max Delbrueck Centrum, December 26, 2007: EP1870420-A1 (1 worldwide citation)


The present invention is related to a peptide comprising an amino acid sequence according to SEQ. ID. No 1.



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