Wanker Erich, Lalowski Maciej, Stelzl Ulrich, Stroedicke Martin, Haenig Christian, Worm Uwe, Goehler Heike: Method for the identification of protein-protein interactions in disease related protein networks. Max Delbrueck Centrum, July 5, 2006: EP1677113-A1 (10 worldwide citation)

The present invention relates to a method for identification of a protein-protein interaction of protein interaction partners in a disease-related network of proteins comprising the steps of (a) identifying nucleic acid molecules by at least partial 5'sequencing and, optionally, additionally adding ...

Human-derived T cell receptors. Max Delbrueck Centrum, May 19, 2010: EP2186825-A1 (6 worldwide citation)

The invention pertains to a human-derived T cell receptor (mhTCR) that, compared to the human wild-type T cell receptor (wtTCR), bears mutations at certain sites of the constant TCR beta region 2 (C2) or the constant TCR beta region 1 (C1) and the constant TCR alpha region (C+-). The presence of the ...

Blankenstein Thomas, Uckert Wolfgang, Kieback Elisa, Charo Jehad: Epitope-tag for surface-expressed t-cell receptor proteins, uses thereof and method of selecting host cells expressing them. Max Delbrueck Centrum, January 16, 2008: EP1878744-A1 (5 worldwide citation)

The present invention relates to a method for selecting a host cell population expressing a functional fusion protein comprising at least one epitope-providing amino acid sequence (epitope-tag) and the amino acid sequence of a protein that is expressed on the surface of said host cell. Preferably, t ...

Wallukat Gerd, Kunze Rudolf, Herrmann Martin, Voll Reinhard, Juenemann Anselm, Schloetzer Ursula: Peptides against autoantibodies associated with glaucoma and use of these peptides. Max Delbrueck Centrum, Univ Friedrich Alexander Er, Fresenius Medical Care de, September 12, 2007: EP1832600-A1 (4 worldwide citation)

The invention relates to nucleic acid molecules encoding peptides which interact with autoantibodies associated with glaucoma, to the peptides themselves, to a pharmaceutical composition comprising said nucleic acid molecules and peptides, and to the use of said peptides - especially in apheresis - ...

Dolores Schendel, Susanne Wilde, Thomas Blankenstein: Generation of antigen specific T cells. Helmholtz Zentrum Muenchen Deutsches Forschungzentrum fuer Gesundheit und Umwelt, Max Delbrueck Centrum fuer Molekulare Medizin, Jenkins Wilson Taylor & Hunt P A, July 16, 2013: US08486694 (2 worldwide citation)

The present invention is directed to a method of generating antigen specific T cells. Furthermore, the invention is directed to antigen specific T cells, isolated transgenic TCR's, pharmaceutical compositions containing same and their use in adoptive cell therapy. This invention in particular pertai ...




Gotthardt Michael, Radke Michael: Inducible site-directed mutagenesis through conditional gene rescue. Max Delbrueck Centrum, October 13, 2004: EP1466974-A1 (1 worldwide citation)

The present invention relates to a conditionally inducible site-directed mutant cell, comprising a mutated allele of a gene; wherein said allele comprises a mutation that was introduced by using a suitable mutagenesis technique, a rescue allele of said mutated gene that can be conditionally inactiva ...

WANKER ERICH PROF DR, WIGLENDA THOMAS DR, BABILA JULIUS TACHU DR, BOEDDRICH ANNETT DR, SCHMIDT MICHAEL DR, NEUENDORF SANDRA, SCHIELE FRANZISKA: [fr] Activateurs de dégradation de protéine, [de] Verstärker des Proteinabbaus, [en] Enhancers of protein degradation. MAX DELBRUECK CENTRUM, February 23, 2011: EP2287149-A1 (1 worldwide citation)

[en] The present invention relates to compounds suitable for modulating huntingtin protein processing and useful for treating or preventing huntingtin-related disorders. The invention provides pharmaceutical compositions comprising said compounds and methods of syntheses thereof.

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