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Wanker Erich, Lalowski Maciej, Stelzl Ulrich, Stroedicke Martin, Haenig Christian, Worm Uwe, Goehler Heike: Method for the identification of protein-protein interactions in disease related protein networks. Max Delbrueck Centrum, July 5, 2006: EP1677113-A1 (7 worldwide citation)


The present invention relates to a method for identification of a protein-protein interaction of protein interaction partners in a disease-related network of proteins comprising the steps of (a) identifying nucleic acid molecules by at least partial 5'sequencing and, optionally, additionally adding ...


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Blankenstein Thomas, Uckert Wolfgang, Kieback Elisa, Charo Jehad: Epitope-tag for surface-expressed t-cell receptor proteins, uses thereof and method of selecting host cells expressing them. Max Delbrueck Centrum, January 16, 2008: EP1878744-A1 (4 worldwide citation)


The present invention relates to a method for selecting a host cell population expressing a functional fusion protein comprising at least one epitope-providing amino acid sequence (epitope-tag) and the amino acid sequence of a protein that is expressed on the surface of said host cell. Preferably, t ...


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Wallukat Gerd, Kunze Rudolf, Herrmann Martin, Voll Reinhard, Juenemann Anselm, Schloetzer Ursula: Peptides against autoantibodies associated with glaucoma and use of these peptides. Max Delbrueck Centrum, Univ Friedrich Alexander Er, Fresenius Medical Care de, September 12, 2007: EP1832600-A1 (2 worldwide citation)


The invention relates to nucleic acid molecules encoding peptides which interact with autoantibodies associated with glaucoma, to the peptides themselves, to a pharmaceutical composition comprising said nucleic acid molecules and peptides, and to the use of said peptides - especially in apheresis - ...


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Human-derived T cell receptors. Max Delbrueck Centrum, May 19, 2010: EP2186825-A1 (2 worldwide citation)


The invention pertains to a human-derived T cell receptor (mhTCR) that, compared to the human wild-type T cell receptor (wtTCR), bears mutations at certain sites of the constant TCR beta region 2 (C2) or the constant TCR beta region 1 (C1) and the constant TCR alpha region (C+-). The presence of the ...


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Gotthardt Michael, Radke Michael: Inducible site-directed mutagenesis through conditional gene rescue. Max Delbrueck Centrum, October 13, 2004: EP1466974-A1 (1 worldwide citation)


The present invention relates to a conditionally inducible site-directed mutant cell, comprising a mutated allele of a gene; wherein said allele comprises a mutation that was introduced by using a suitable mutagenesis technique, a rescue allele of said mutated gene that can be conditionally inactiva ...


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Schmetzer Oliver, Pezzutto Antonio: Peptides regulating the surface expression of the t cell receptor. Max Delbrueck Centrum, December 26, 2007: EP1870420-A1 (1 worldwide citation)


The present invention is related to a peptide comprising an amino acid sequence according to SEQ. ID. No 1.


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Boettger Michael Dr, Zaitsev Sergei, Cartier Regis, Haberland Annekathrin Dr, Sukhorukov Gleb Dr, Zastrow Heidi, Schneider Marc, Moehwald Helmut Prof Dr: Preparation and use of dna-polyelectrolyte nanoparticles for gene transfer. Max Delbrueck Centrum, Max Planck Gesellschaft, October 22, 2003: EP1354958-A1 (1 worldwide citation)


A method of gene transfer into animal cells in which vector DNA (A), in aqueous solution, is packaged into compact nanoparticles (NP) by sequential addition of oppositely charged polyelectrolytes (PE), then NP are used for transfection, is new.



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