1
Jeffrey A Hubbell, Chandrashekhar P Pathak, Amarpreet S Sawhney, Neil P Desai, Jennifer L Hill, Syed F A Hossainy: Gels for encapsulation of biological materials. Board of Regents The University of Texas System, Arnall Golden & Gregory, January 12, 1999: US05858746 (476 worldwide citation)


Water soluble macromers are modified by addition of free radical polymerizable groups, such as those containing a carbon-carbon double or triple bond, which can be polymerized under mild conditions to encapsulate tissues, cells, or biologically active materials. The polymeric materials are particula ...


2
Samir S Mitragotri, Daniel Blankschtein, Robert S Langer: Transdermal delivery of encapsulated drugs. Massachusetts Insitiute of Technology, Arnall Golden & Gregory, September 29, 1998: US05814599 (461 worldwide citation)


Applications of low-frequency (20 KHz) ultrasound enhances transdermal transport of high-molecular weight proteins. This method includes a simultaneous application of ultrasound and protein on the skin surface in order to deliver therapeutic doses of proteins across the skin. Examples demonstrate in ...


3
Laurence A Roth, Stephen Jack Herman: Targeted delivery via biodegradable polymers. Focal, Arnall Golden & Gregory, March 9, 1999: US05879713 (417 worldwide citation)


Delivery of bioactive molecules such as nucleic acid molecules encoding a protein can be significantly enhanced by immobilization of the bioactive molecule in a polymeric material adjacent to the cells where delivery is desired, where the bioactive molecule is encapsulated in a vehicle such as lipos ...


4
Paul M Lizardi: Rolling circle replication reporter systems. Yale University, Arnall Golden & Gregory, December 29, 1998: US05854033 (387 worldwide citation)


Disclosed are compositions and a method for of amplifying nucleic acid sequences useful for detecting the presence of molecules of interest. The method is useful for detecting specific nucleic acids in a sample with high specificity and sensitivity. The method also has an inherently low level of bac ...


5
John T Santini Jr, Michael J Cima, Robert S Langer: Microchip drug delivery devices. Massachusetts Institute of Technology, Arnall Golden & Gregory, August 25, 1998: US05797898 (381 worldwide citation)


Microchips are provided, which control both the rate and time of release of multiple chemical substances and which allow for the release of a wide variety of molecules in either a continuous or pulsatile manner. In all of the preferred embodiments, a material that is impermeable to the drugs or othe ...


6
Ruxandra Gref, Yoshiharu Minamitake, Robert S Langer: Biodegradable injectable nanoparticles. Massachusetts Institute of Technology, Arnall Golden & Gregory, August 6, 1996: US05543158 (366 worldwide citation)


Particles are provided that are not rapidly cleared from the blood stream by the macrophages of the reticuloendothelial system, and that can be modified to achieve variable release rates or to target specific cells or organs. The particles have a biodegradable solid core containing a biologically ac ...


7
Robert S Langer, Andreas Lendlein, Annette Schmidt, Hans Grablowitz: Biodegradable shape memory polymers. Massachusetts Institute of Technology, Arnall Golden & Gregory, December 12, 2000: US06160084 (340 worldwide citation)


Biodegradable shape memory polymer compositions, articles of manufacture thereof, and methods of preparation and use thereof are described. In one embodiment the compositions include at least one hard segment and at least one soft segment. The T.sub.trans of the hard segment is preferably between -3 ...


8
Joseph Kost, Uwe Pliquett, Samir S Mitragotri, Robert S Langer, James C Weaver: Effect of electric field and ultrasound for transdermal drug delivery. Massachusetts Institute of Technology, Arnall Golden & Gregory, March 21, 2000: US06041253 (339 worldwide citation)


Transdermal transport of molecules during sonophoresis (delivery or extraction) can be further enhanced by application of an electric field, for example, electroporation or iontophoresis. In a preferred embodiment the ultrasound is low frequency ultrasound which induces cavitation of the lipid layer ...


9
Justin Hanes, David A Edwards, Carmen Evora, Robert Langer: Particles incorporating surfactants for pulmonary drug delivery. Massachusetts Instite of Technology, The Penn State Research Foundation, Arnall Golden & Gregory, January 5, 1999: US05855913 (314 worldwide citation)


Aerodynamically light particles incorporating a surfactant on the surface thereof for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the aerodynamically light particles are made of a biodegradable material and have a ...


10
Abraham J Domb, Ruxandra Gref, Yoshiharu Minamitake, Maria Teresa Peracchia, Robert S Langer: Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers. Massachusetts Institute of Technology, Arnall Golden & Gregory, December 28, 1999: US06007845 (307 worldwide citation)


Particles are provided that are not rapidly cleared from the blood stream by the macrophages of the reticuloendothelial system, and that can be modified to achieve variable release rates or to target specific cells or organs. The particles have a core of a multiblock copolymer formed by covalently l ...



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