1
Edwin F Ullman, Thomas C Goodman, Paul D Stull: Method for detection of specific nucleic acid sequences. Syntex, Theodore J Leitereg, Mark L Bosse, February 9, 1993: US05185243 (162 worldwide citation)


A method is disclosed for detecting the presence of a target nucleotide sequence in a polynucleotide. The method comprises hybridizing a first nucleotide sequence and a second nucleotide sequence to non-contiguous portions of a target nucleotide sequence, covalently attaching the first and second se ...


2
Linda Griffin, Glenn Albrecht, John Latham, Lawrence Leung, Eric Vermaas, John J Toole: Aptamers specific for biomolecules and methods of making. Gilead Sciences, Mark L Bosse, May 26, 1998: US05756291 (150 worldwide citation)


A method for identifying oligomer sequences, optionally comprising modified base, which specifically bind target molecules such as serum proteins, kinins, eicosanoids and extracellular proteins is described. The method is used to generate aptamers that bind to serum Factor X, PDGF, FGF, ICAM, VCAM, ...


3
Brian Froehler: Oligonucleotides with inverted polarity. Gilead Sciences, Mark L Bosse, June 18, 1996: US05527899 (129 worldwide citation)


Oligonucleotides having tandem sequences of inverted polarity, i.e., oligonucleotides comprising regions of the formula: ##STR1## wherein --C-- symbolizes any method of coupling the nucleotide sequence of opposite polarity, are useful for forming an extended triple helix with a double-helical nucleo ...


4
Brian C Froehler, Chris A Buhr: Nucleoside hydrogen phosphonodithioate diesters and activated phosphonodithioate analogues. Gilead Sciences, Mark L Bosse, October 15, 1996: US05565555 (108 worldwide citation)


Novel hydrogen-phosphonodithioate compositions are provided which are particularly useful for forming internucleotide and internucleoside linkages in oligonucleosides or oligonucleotides, The oligonucleotides and analogs thereof made by using the hydrogen-phosphonodithioate compositions may be thera ...


5
Edwin F Ullman, Pyare Khanna, Rohan Peries: Immunoassay device. Syntex, Theodore J Leitereq, Mark L Bosse, August 11, 1992: US05137808 (85 worldwide citation)


A device is disclosed for conducting an assay method. The device comprises a housing, means enclosed in the housing for capturing a member of a specific binding pair in a zone and for allowing liquid to be transported by capillary action away from the zone, one or more self-contained liquid reagents ...


6
John J Toole, Linda C Griffin, Louis C Bock, John A Latham: Aptamer analogs specific for biomolecules. Gilead Sciences, Mark L Bosse, November 24, 1998: US05840867 (83 worldwide citation)


Oligonucleotide sequences that mediate specific binding to selected target molecules and contain modified base, sugars, or sugar linkages are disclosed. Single-stranded DNA oligomers are obtained that bind to a series of biomolecules that differ in both size and composition. The range of target mole ...


7
John Vorpahl: Method of separation employing magnetic particles and second medium. Syntex, Theodore J Leitereg, Mark L Bosse, January 18, 1994: US05279936 (66 worldwide citation)


Methods are disclosed for separating a component of interest from a mixture containing the component of interest and other components. The method comprises contacting a first liquid medium containing the component of interest and other components with a second liquid medium that is of different dens ...


8
Thomas L Tarnowski, Cheng I Lin, Edwin F Ullman: Reversible agglutination mediators. Syntex, Theodore J Leitereg, Mark L Bosse, August 4, 1992: US05136095 (54 worldwide citation)


Compounds and methods are disclosed for reversibly aggregating particles suspended in a liquid medium. The method comprises combining the liquid medium containing the particles with a polyionic polymer capable of aggregating the particles under conditions suitable for such aggregation. Thereafter, t ...


9
Sharat Singh, Arthur C Switchenko, Cheng I Lin, Nurith Kurn, Edwin F Ullman: Method and kits for determining peroxidatively active catalysts. Behringwerke, Theodore J Leitereg, Mark L Bosse, Janet Kaku, July 2, 1996: US05532138 (34 worldwide citation)


Methods and compositions are disclosed for determining a peroxidatively active catalyst. The methods comprise the step of detecting a substance formed by the coupling reaction of (a) the product of the peroxidatively active catalyst-catalyzed oxidation of a benzidine with (b) a coupler other than be ...


10
Kenneth K Inouye: Evaporation closure. Syntex, Mark L Bosse, Theodore J Leitereg, March 1, 1994: US05289930 (34 worldwide citation)


An evaporation closure is disclosed. One embodiment of the closure includes a cap, made of pliable material, which in turn includes a top wall having an opening, a skirt downwardly depending from the top wall and having a threadless internal wall adapted to slip on and sealingly engage a container, ...



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