1
Donald M Engelman, John F Hunt: Transmembrane polypeptide and methods of use. Yale University April 14, 1998: US05739273 (8 worldwide citation)


A water-soluble polypeptide having the characteristics of the bacteriorhodopsin C helix such that it is largely hydrophobic and spontaneously inserts into a biological membrane as an alpha-helix. The polypeptide is administered as an aqueous solution or is contained within the lipid bilayer of a lip ...


2
Martin W Stryker, Donald M Engelman: Drug delivery system. Stryker Corporation November 1, 2011: US08048044 (2 worldwide citation)


A drug delivery system including a chamber, which is configured for enclosing or covering at least a surface of a patient, a source of a drug, and a pressure source, which selectively pressurizes the chamber. In addition, the system includes a controller for controlling the transfer of the drug to t ...


3
Yana K Reshetnyak, Oleg A Andreev, Ursula Lehnert, Donald M Engelman: Selective delivery of molecules into cells or marking of cells in diseased tissue regions using environmentally sensitive transmembrane peptide. Board of Governors for Higher Education State of Rhode Island and Providence Plantations, Yale University December 13, 2011: US08076451


A polypeptide with a predominantly hydrophobic sequence long enough to span a membrane lipid bilayer as a transmembrane helix (TM) and comprising one or more dissociable groups inserts across a membrane spontaneously in a pH-dependant fashion placing one terminus inside cell. The polypeptide conjuga ...


4
Yana K Reshetnyak, Oleg A Andreev, Ursula Lehnert, Donald M Engelman: Selective delivery of molecules into cells or marking of cells in diseased tissue regions using environmentally sensitive transmembrane peptide. Yale University April 22, 2014: US08703909


A polypeptide with a predominantly hydrophobic sequence long enough to span a membrane lipid bilayer as a transmembrane helix (TM) and comprising one or more dissociable groups inserts across a membrane spontaneously in a pH-dependant fashion placing one terminus inside cell. The polypeptide conjuga ...


5
Martin W Stryker, Donald M Engelman: Drug delivery system. Stryker Corporation February 19, 2009: US20090048555-A1


A drug delivery system including a chamber, which is configured for enclosing or covering at least a surface of a patient, a source of a drug and a pressure source, which selectively pressurizes the chamber. In addition, the system includes a controller for controlling the transfer of the drug to th ...


6
Yana K Reshetnyak, Oleg A Andreev, Donald M Engelman: Liposome Compositions and Methods of Use Thereof. February 16, 2012: US20120039990-A1


The present application relates to compositions comprising and methods of using a liposome comprising a pHLIP polypeptide, wherein a lipid bilayer of the liposome is substantially free of the pHLIP polypeptide.


7
Martin W Stryker, Donald M Engelman: Drug delivery system. Stryker Corporation March 15, 2012: US20120065576-A1


A drug delivery system including a chamber, which is configured for enclosing or covering at least a surface of a patient, a source of a drug and a pressure source, which selectively pressurizes the chamber. In addition, the system includes a controller for controlling the transfer of the drug to th ...



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