1
Smadar Cohen, Alexander K Andrianov, Margaret Wheatley, Harry R Allcock, Robert S Langer: Gas-filled polymeric microbubbles for ultrasound imaging. Massachusetts Institute of Technology, The Penn State Research Foundation, Arnall Golden & Gregory, January 30, 1996: US05487390 (132 worldwide citation)


Compositions, methods for preparing and methods of using air-filled polymeric microcapsules for ultrasound imaging are disclosed. Air-encapsulating microcapsules are formed by ionotropically gelling synthetic polyelectrolytes such as poly(carboxylatophenoxy)phosphazene, poly(acrylic acid), poly(meth ...


2
Alexander K Andrianov, Robert S Langer: Method for making hydrophobic polymeric microparticles. Massachusetts Institute of Technology and Virus Research Institute, Arnall Golden & Gregory, March 19, 1996: US05500161 (52 worldwide citation)


A method for the preparation of microparticles, and the product thereof, that includes dispersing a substantially water insoluble non-ionic or ionic polymer in an aqueous solution in which the substance to be delivered is also dissolved, dispersed or suspended, and then coagulating the polymer toget ...


3
Harry R Allcock, Alexander K Andrianov, Robert S Langer, Karyn B Visscher: Phosphazene polyelectrolytes as immunoadjuvants. Massachusetts Institute of Technology, Virus Research Institute, The Penn State Research Foundation, Arnall Golden & Gregory, October 8, 1996: US05562909 (45 worldwide citation)


A immunoadjuvant soluble phosphazene polyelectrolyte is disclosed. In one embodiment, the polymeric adjuvant is an poly(organophosphazene) with (i) ionized or ionizable pendant groups that contain, for example, carboxylic acid, sulfonic acid, or hydroxyl moieties, and (ii) pendant groups that are su ...


4
Smadar Cohen, Alexander K Andrianov, Margaret Wheatley, Harry R Allcock, Robert S Langer: Polymeric microparticles containing agents for imaging. Massachusetts Institute of Technology, The Penn State Research Foundation, Arnall Golden & Gregory, October 8, 1996: US05562099 (41 worldwide citation)


Compositions, methods for preparing and methods of using contrast agent-filled polymeric microparticles for imaging are disclosed. In a preferred embodiment, air-encapsulating microparticles are formed by ionotropically gelling synthetic polyelectrolytes such as poly(carboxylatophenoxy)phosphazene, ...


5
Alexander K Andrianov, Sharon A Jenkins, Lendon G Payne, Bryan E Roberts: Hydrogel microencapsulated vaccines. Virus Research Institute, Elliot M Olstein, Raymond J Lillie, Gregory D Ferraro, June 25, 1996: US05529777 (32 worldwide citation)


Water soluble polymers or polymeric hydrogels are used to encapsulate antigen to form vaccines. The antigen is mixed with a polymer solution, microparticles are formed of the polymer and antigen, and, optionally, the polymer is crosslinked to form a stable microparticle. Preferred polymers are algin ...


6
Alexander K Andrianov, Sharon A Jenkins, Lendon G Payne, Bryan E Roberts: Phosphazene polyelectrolytes as immunoadjuvants. Virus Research Institute, Elliot M Olstein, February 27, 1996: US05494673 (20 worldwide citation)


An immunoadjuvant soluble polyphosphazene polyelectrolyte is disclosed. In one embodiment, the polymeric adjuvant is an poly(organophosphazene) with (i) ionized or ionizable pendant groups that contain, for example, carboxylic acid, sulfonic acid, or hydroxyl moieties, and (ii) pendant groups that a ...


7
Alexander K Andrianov, Lendon G Payne, Jonathan R Sargent, Sameer S Sule: Polyphosphazene polyelectrolyte immunoadjuvants. Virus Research Institute, Elliot M Olstein, Raina Semionow, January 5, 1999: US05855895 (11 worldwide citation)


A polyphosphazene polyelectrolyte immunoadjuvant having improved water solubility, a vaccine composition of the immunoadjuvant and an antigen or immunogen and methods of their use in producing or enhancing an immunoprotective response in a host are disclosed.


8
Alexander K Andrianov, Jonathan R Sargent, Sameer S Sule: Recovery of polyphosphazene polyacids or acids salts thereof. Virus Research Institute, Elliot M Olstein, Raymond J Lillie, September 29, 1998: US05814704 (9 worldwide citation)


A process for recovering a polyphosphazene polyacid or acid salt obtained by hydrolyzing a polyphosphazene having at least one ester moiety present in at least one substituent group. The polyphosphazene having at least one ester moiety present in at least one substituent group is hydrolyzed with a b ...


9
Alexander K Andrianov, Jonathan R Sargent, Sameer S Sule, Mark LeGolvan: Polyhalophosphazene solutions stable against gelation. Virus Research Institute, Elliot M Olstein, Raymond J Lillie, January 13, 1998: US05707597 (9 worldwide citation)


A solution which comprises a polyphosphazene solute, such as a polyhalophosphazene solute, and a stabilizing solvent such as diglyme. Such solution enables the polyphosphazene to remain stable for extended periods of time so that such polyhalophosphazenes may be employed for further modification or ...


10
Alexander K Andrianov, Jianping Chen: Preparation of ionically cross-linked polyphosphazene microspheresy by coacervation. Virus Research Institute, Elliot M Olstein, Raymond J Lillie, September 15, 1998: US05807757 (8 worldwide citation)


A method is provided for preparing polyphosphazene microspheres wherein the polyphosphazene microspheres are produced by coacervation. A solution containing a polyphosphazene is admixed with a solution containing a salt of a monovalent ion such as a salt of a Group I element (for example, NaCl) to f ...



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