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Christopher R Roberts, Michael McMahon, Steven R Slawson: Body cavity irrigation system. Welch Allyn, Wall Marjama & Bilinski, November 26, 2002: US06485451 (48 worldwide citation)


A body cavity irrigation system includes a housing having at least one interior chamber which is connectable to a faucet or other continuous fluid supply which delivers liquid under pressure through an inlet port. A discharge port of the housing is fluidly interconnected to an irrigation syringe hav ...


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Charles A Dvorak, Douglas L Wren, Lawrence E Fisher, Steven D Axt, Eric R Humphreys, Humberto B Arzeno, Colin C Beard, Sam Linh Nguyen, Yeun Kwei Han, Christopher R Roberts, Jan P Lund, Paul R Fatheree: Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative. Syntex, Heller Ehrman White & McAuliffe, March 21, 2000: US06040446 (3 worldwide citation)


Process and novel intermediates for preparing the L-mono-valine ester of 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol and its pharmaceutically acceptable salts. The present process and intermediates provide for reduced impurities in the mono-valine ester end-product and lower over ...


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Humberto B Arzeno, Eric R Humphreys, Jim Wah Wong, Christopher R Roberts: Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative. Syntex, Heller Ehrman White & McAuliffe, November 24, 1998: US05840890 (2 worldwide citation)


Process and novel intermediates for preparing the mono-L-valine ester of 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol ganciclovir) and its pharmaceutically acceptable salts. The present process and monoester intermediates provide for mono-esterification by an L-valine derivative, ...


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Humberto B Arzeno, Eric R Humphreys, Jim Wah Wong, Christopher R Roberts: Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative. Syntex, Heller Ehrman White & McAuliffe, August 15, 2000: US06103901 (2 worldwide citation)


Intermediates of Formula (III) ##STR1## wherein P.sup.1 is hydrogen or an amino-protecting group, R is lower alkyl, allyl or aralkyl, and Z is hydrogen, lower alkyl, aryl or aralkyl; and Formula (VI) ##STR2## wherein P.sup.1 is hydrogen or an amino-protecting group, P.sup.2 is an amino protecting gr ...


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Christopher R Roberts, Jim wah Wong: -Acyl-5′-deoxy-5-fluorocytidine, Process for producing N. Roche Colorado Corporation, Faegre & Benson, April 29, 2008: US07365188 (2 worldwide citation)


The present invention provides a process for producing a N4-acyl-5′-deoxy-5-fluorocytidine compound of the formula: where R2 is alkyl, cycloalkyl, aralkyl, aryl, or alkoxy.


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Lin Chen, Yeun Kwei Han, Christopher R Roberts: Insulinotropic peptide synthesis using solid and solution phase combination techniques. Roche Palo Alto, Brian L Buckwalter, July 24, 2012: US08227571


The present invention relates to the preparation of insulinotropic peptides that are synthesized using a solid and solution phase (“hybrid”) approach. Generally, the approach includes synthesizing three different peptide intermediate fragments using solid phase chemistry. Solution phase chemistry is ...


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Lin Chen, Christopher R Roberts: Methods for the synthesis of arginine-containing peptides. Roche Colorado Corporation, August 2, 2007: US20070179279-A1


Methods for the synthesis of arginine-containing peptides are provided. The methods include a step that minimizes contact of side chain protected arginine with base prior to the coupling step.



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