1
Darwin J Prockop, Ruth F Pereira, Dennis B Leeper, Michael D O Hara: Isolated stromal cells for treating diseases, disorders or conditions characterized by bone defects. Thomas Jefferson University, Woodcock Washburn Kurtz Mackiewicz & Norris, February 10, 1998: US05716616 (113 worldwide citation)


Methods of treating patients who are suffering from a disease, disorder or condition characterized by a bone cartilage or lung defect are disclosed. The methods comprising the step of intravenous administration of stromal cells isolated from normal syngeneic individuals or intravenous administration ...


2
James J Earley, Gerardus C Tromp, Darwin J Prockop, Sisko H Kuivaniemi: Apparatus for robotically performing sanger dideoxynucleotide DNA sequencing reactions using controlled pipet. Thomas Jefferson University, Woodcock Washburn Kurtz Mackiewicz & Norris, October 3, 1995: US05455008 (68 worldwide citation)


A robotic system for performing nucleic acid sequencing reactions in microtiter plate format. The robot has a robot arm and its controller, robot hands with which it can manipulate microtiter plates with lids and microtiter plates without lids and with which it can perform pipetting in the 5 to 200 ...


3
Darwin J Prockop, Jaspal Khillan, Shi Wu Li, Ruth Pereira: Use of a COL1A1 mini-gene construct to inhibit collagen synthesis. Thomas Jefferson University, Pennie & Edmonds, July 28, 1998: US05786341 (21 worldwide citation)


Methods are provided for controlling the synthesis of protein from the human gene for the pro.alpha.1(I) chain of type I procollagen in cells using mini-gene constructs which are injected into cells which synthesize the protein. Methods for controlling collagen deposition in tissue mini-gene constru ...


4
Darwin J Prockop, David C Colter, Ichiro Sekiya: Early stage multipotential stem cells in colonies of bone marrow stromal cells. Tulane University, Philadelphia Heath and Education Corporation, Drinker Biddle & Reath, June 6, 2006: US07056738 (21 worldwide citation)


Marrow stromal cells (MSCS) are adult stem cells from bone marrow that can differentiate into multiple non-hematopoietic cell lineages. Colonies of human MSCs were shown to contain both small, rapidly self-renewing stem cells (RS cells) and large, more mature cells (mMSCs). Samples enriched for RS c ...


5
Darwin J Prockop, Leena Ala Kokko, Andrzej Fertala, Aleksander Sieron, Kari I Kivirikko, Amy Geddis, Taina Pihlajaniemi: Synthesis of human procollagens and collagens in recombinant DNA systems. Thomas Jefferson University, Albert P Pennie & Edmonds Halluin Esq, January 14, 1997: US05593859 (19 worldwide citation)


The invention is transfected cells, substantially all of which contain at least one human collagen gene and express fibrillar collagen molecules derived using methods for synthesizing collagen and collagen fibrils in said cell lines, and methods for treatment of disorders in humans using said collag ...


6
Darwin J Prockop, David G Stokes, S Ausim Azizi: Isolated stromal cells for use in the treatment of diseases of the central nervous system. CP Hahnemann University, Morgan Lewis & Bockius, November 25, 2003: US06653134 (17 worldwide citation)


Methods of treating a human patient having a disease, disorder or condition of the central nervous system are disclosed. The methods include obtaining a bone marrow sample from a human donor, isolating stromal cells from the bone marrow sample, and administering the isolated stromal cells to the cen ...


7
Darwin J Prockop: Collagen inhibiting compositions and processes for manufacturing and using same. Louis E Marn, Elliot M Olstein, January 31, 1984: US04428939 (13 worldwide citation)


There is disclosed the use of a collagen inhibiting composition including in polymeric form select analogs of proline and processes for the manufacture and use of such a collagen-inhibiting composition to reduce scar tissue formation.


8
Darwin J Prockop: Method of treating the effectiveness of collagen-inhibiting compositions. University of Medicine and Dentistry of New Jersey, David A Jackson, June 9, 1987: US04672031 (9 worldwide citation)


There is disclosed the use of a collagen inhibiting composition including in polymeric form select analogs of proline and processes for the manufacture and use of such a collagen-inhibiting composition to reduce scar tissue formation. There is also disclosed a method for testing the effectiveness of ...


9
Darwin J Prockop, Leena Ala Kokko, Andrzej Fertala, Aleksander Sieron, Kari I Kivirikko, Amy Geddis: Synthesis of human procollagens and collagens in recombinant DNA systems. Thomas Jefferson University, Woodcock Washburn Kurtz Mackiewicz & Norris, April 11, 1995: US05405757 (8 worldwide citation)


The invention is stably transfected cells, substantially all of which contain at least one human collagen gene and express fibrillar collagen molecules derived using methods for synthesizing collagen and collagen fibrils in said cell lines, and methods for treatment of disorders in humans using said ...


10
Darwin J Prockop, Loretta D Spotila, Constantinos D Deltas, Larisa Sereda, Andrea Westerhausen Larson, Michael Pack, Alain Colige, James Early, Jarmo Körkkö, Leena Ala Kokko, Susanna Annunen, Tero Pihlajamaa, Mirko Vuoristo, Petteri Paassilta: Compositions and methods for detecting altered COL1A1 gene sequences. Allegheny University of the Health Sciences, Thomas Jefferson University, University of Oulu, Morgan Lewis & Bockius L, July 24, 2001: US06265157 (7 worldwide citation)


Compositions and methods useful for determining whether a subject has an alteration in a gene encoding a protein chain of Type I or Type IX collagen are described. Novel intronic sequences of five human genes, COL1A1, COL1A2, COL9A1, COL9A2, and COL9A3 are described. Methods of determining the exist ...



Click the thumbnails below to visualize the patent trend.