1
Smadar Cohen, Carmen Bano, Karyn B Visscher, Marie Chow, Harry R Allcock, Robert S Langer: Ionically cross-linked polymeric microcapsules. Massachusetts Institute of Technology, Pennsylvania Research Corporation, Kilpatrick & Cody, September 22, 1992: US05149543 (169 worldwide citation)


A method for encapsulating biologically-labile materials such as proteins, liposomes, bacteria and eucaryotic cells within a synthetic polymeric capsule, and the product thereof, are disclosed. The method is based on the use of a water-soluble polymer with charged side chains that are crosslinked wi ...


2
Smadar Cohen, Alexander K Andrianov, Margaret Wheatley, Harry R Allcock, Robert S Langer: Gas-filled polymeric microbubbles for ultrasound imaging. Massachusetts Institute of Technology, The Penn State Research Foundation, Arnall Golden & Gregory, January 30, 1996: US05487390 (132 worldwide citation)


Compositions, methods for preparing and methods of using air-filled polymeric microcapsules for ultrasound imaging are disclosed. Air-encapsulating microcapsules are formed by ionotropically gelling synthetic polyelectrolytes such as poly(carboxylatophenoxy)phosphazene, poly(acrylic acid), poly(meth ...


3
Harry R Allcock, Paul E Austin, Sukky Kwon: Water-soluble phosphazene polymers having pharmacological applications. Research Corporation Technologies, Scully Scott Murphy & Presser, November 14, 1989: US04880622 (67 worldwide citation)


Novel poly(organophosphazene) polymers are used for the controlled release of pharmaceuticals, pesticides, herbicides, plant growth regulators and fertilizers. These polymers also act as foam control agents.


4
Harry R Allcock, Paul E Austin, Thomas X Neenan: Anesthetic polyorganophosphazenes. Research Corporation, Scully Scott Murphy & Presser, January 22, 1985: US04495174 (66 worldwide citation)


A long-acting, local anesthetic, comprising a polymeric phosphazene backbone, and 2-amino-4-picoline radical having local anesthetic activity and an amino functional group on the ring of said radical through which said radical is covalently attached to the phosphazene backbone by a phosphorous-nitro ...


5
Harry R Allcock, Thomas X Neenan, Walter C Kossa: Coupling of polyorganophosphazenes to carboxylic acid. Research Corporation, Scully Scott Murphy & Presser, April 3, 1984: US04440921 (65 worldwide citation)


A carboxylated phosphazene polymer, comprising a phosphazene polymer backbone covalently coupled to a carboxylate-containing compound through a divalent organic radical attached at one end to the carboxylate by an amide bond formed at a primary aliphatic amino group of the radical and at the other e ...


6
Smadar Cohen, Carmen Bano, Karyn B Visscher, Marie Chow, Harry R Allcock, Robert S Langer: Ionically cross-linked polymeric microcapsules. Massachusetts Institute of Technology, The Penn State Research Foundation, Arnall Golden & Gregory, February 27, 1996: US05494682 (54 worldwide citation)


A method for encapsulating biologically-labile materials such as proteins, liposomes, bacteria and eucaryotic cells within a synthetic polymeric capsule, and the product thereof, are disclosed. The method is based on the use of a water-soluble polymer with charged side chains that are crosslinked wi ...


7
Cato T Laurencin, Lakshmi Sreedharan Nair, Subhabrata Bhattacharyya, Harry R Allcock, Jared D Bender, Paul W Brown, Yaser E Greish: Polymeric nanofibers for tissue engineering and drug delivery. June 26, 2007: US07235295 (50 worldwide citation)


Polymeric nanofibers have been developed which are useful in a variety of medical and other applications, such as filtration devices, medical prosthesis, scaffolds for tissue engineering, wound dressings, controlled drug delivery systems, cosmetic skin masks, and protective clothing. These can be fo ...


8
Smadar Cohen, Carmen Bano, Karyn B Visscher, Marie B Chow, Harry R Allcock, Robert S Langer: Ionically cross-linked polymeric microcapsules. May 3, 1994: US05308701 (46 worldwide citation)


A method for encapsulating biologically-labile materials such as proteins, liposomes, bacteria and eucaryotic cells within a synthetic polymeric capsule, and the product thereof, are disclosed. The method is based on the use of a water-soluble polymer with charged side chains that are crosslinked wi ...


9
Harry R Allcock, Alexander K Andrianov, Robert S Langer, Karyn B Visscher: Phosphazene polyelectrolytes as immunoadjuvants. Massachusetts Institute of Technology, Virus Research Institute, The Penn State Research Foundation, Arnall Golden & Gregory, October 8, 1996: US05562909 (45 worldwide citation)


A immunoadjuvant soluble phosphazene polyelectrolyte is disclosed. In one embodiment, the polymeric adjuvant is an poly(organophosphazene) with (i) ionized or ionizable pendant groups that contain, for example, carboxylic acid, sulfonic acid, or hydroxyl moieties, and (ii) pendant groups that are su ...


10
Smadar Cohen, Alexander K Andrianov, Margaret Wheatley, Harry R Allcock, Robert S Langer: Polymeric microparticles containing agents for imaging. Massachusetts Institute of Technology, The Penn State Research Foundation, Arnall Golden & Gregory, October 8, 1996: US05562099 (41 worldwide citation)


Compositions, methods for preparing and methods of using contrast agent-filled polymeric microparticles for imaging are disclosed. In a preferred embodiment, air-encapsulating microparticles are formed by ionotropically gelling synthetic polyelectrolytes such as poly(carboxylatophenoxy)phosphazene, ...



Click the thumbnails below to visualize the patent trend.