1
David A Edwards, Giovanni Caponetti, Jeffrey S Hrkach, Noah Lotan, Justin Hanes, Abdell Aziz Ben Jebria, Robert S Langer: Aerodynamically light particles for pulmonary drug delivery. Massachusetts Institute of Technology, The Penn State Research Foundation, Arnall Golden & Gregory, February 23, 1999: US05874064 (248 worldwide citation)


Improved aerodynamically light particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the aerodynamically light particles are made of a biodegradable material and have a tap density less than 0.4 g/cm.sup.3 and ...


2
David A Edwards, Giovanni Caponetti, Jeffrey S Hrkach, Noah Lotan, Justin Hanes, Abdell Aziz Ben Jebria, Robert S Langer: Aerodynamically light particles for pulmonary drug delivery. Massachusetts Institute of Technology, Penn State Research Foundation, Hamilton Brook Smith & Reynolds P C, October 24, 2000: US06136295 (153 worldwide citation)


Improved aerodynamically light particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the aerodynamically light particles are made of a biodegradable material and have a tap density less than 0.4 g/cm.sup.3 and ...


3
David A Edwards, Giovanni Caponetti, Jeffrey S Hrkach, Noah Lotan, Justin Hanes, Robert S Langer, Abdellaziz Ben Jebria: Porous particles for deep lung delivery. The Penn Research Foundation, Hamilton Brook Smith & Reynolds P C, July 3, 2001: US06254854 (92 worldwide citation)


Improved porous particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the porous particles are made of a biodegradable material and have a mass density less than 0.4 g/cm


4
David A Edwards, Giovannia Caponetti, Jeffrey S Hrkach, Noah Lotan, Justin Hanes, Abdell Aziz Ben Jebria, Robert S Langer: Aerodynamically light particles for pulmonary drug delivery. Massachusetts Institute of Technology, The Penn State Research Foundation, Hamilton Brook Smith & Reynolds P C, January 7, 2003: US06503480 (71 worldwide citation)


Improved aerodynamically light particles for delivery to the pulmonary system, and methods for their preparation and administration are provided. In a preferred embodiment, the aerodynamically light particles are made of a biodegradable material and have a tap density less than 0.4 g/cm


5
Jeffrey S Hrkach, Robert S Langer, Noah Lotan: Functionalized polyester graft copolymers. Massachusetts Institute of Technology, Arnall Golden & Gregory, August 5, 1997: US05654381 (71 worldwide citation)


Synthetic, functionalized, graft copolymers of polyesters and amino acids are provided. The copolymers are formed in one embodiment by providing a linear polyester-poly(amino acid) copolymer, and reacting the amino acid groups in the linear polymer with an amino acid derivative in a polymerization r ...


6
David A Edwards, Giovanni Caponetti, Jeffrey S Hrkach, Noah Lotan, Justin Hanes, Robert S Langer, Abdellaziz Ben Jebria: Porous particles for deep lung delivery. The Penn Research Foundation, Massachusetts Institute of Technology, Hamilton Brook Smith & Reynolds P C, September 10, 2002: US06447753 (69 worldwide citation)


Improved porous particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the porous particles are made of a biodegradable material and have a mass density less than 0.4 g/cm


7
David A Edwards, Giovanni Caponetti, Jeffrey S Hrkach, Noah Lotan, Justin Hanes, Abdellaziz Ben Jebria, Robert S Langer: Aerodynamically light particles for pulmonary drug delivery. October 21, 2003: US06635283 (63 worldwide citation)


Improved aerodynamically light particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the aerodynamically light particles are made of biodegradable material and have a tap density of less than 0.4 g/cm


8
Angela K Dillow, Robert S Langer, Neil Foster, Jeffrey S Hrkach: Supercritical fluid sterilization method. Massachusetts Institute of Technology, Arnall Golden & Gregory, November 21, 2000: US06149864 (37 worldwide citation)


A method is provided for sterilizing materials, particularly polymers, for drug delivery and implantation, wherein the material is treated with supercritical fluid carbon dioxide at pressures in the range of 2000 to 3000 psi (140 to 210 bar) and temperatures preferably between 30 and 45.degree. C. f ...


9
David A Edwards, Giovanni Caponetti, Jeffrey S Hrkach, Noah Lotan, Justin Hanes, Robert S Langer, Abdellaziz Ben Jebria: Porous particles comprising excipients for deep lung delivery. The Penn Research Foundation, Massachesetts Institute of Technology, Hamilton Brook Smith & Reynolds P C, August 20, 2002: US06436443 (35 worldwide citation)


Improved porous particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the porous particles are made of a biodegradable material and have a mass density less than 0.4 g/cm


10
Jeffrey S Hrkach: Low dose pharmaceutical powders for inhalations. Civitas Therapeutics, Elmore Patent Law Group P C, Carolyn S Elmore, Darlene A Vanstone, June 7, 2011: US07954491 (28 worldwide citation)


The invention relates to a method of delivering an agent to the pulmonary system of a compromised patient, in a single breath-activated step, comprising administering a particle mass comprising an agent from an inhaler containing less than 5 milligrams of the mass, wherein at least about 50% of the ...



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