41
Hubert Koster, David M Lough: Beads bound to a solid support and to nucleic acids. Sequenom, Stephanie L Heller Ehrman White & McAuliffe Seidman, October 17, 2000: US06133436 (233 worldwide citation)


Novel compositions comprised of at least one bead conjugated to a solid support and further conjugated to at least one nucleic acid and preferred methods for making the novel compositions are described. As compared to "flat" surfaces, beads linked to a solid support provide an increased surface area ...


42
David R Walt, Karri L Michael: Target analyte sensors utilizing Microspheres. The Trustees of Tufts College, Robin M Silva, David C Foster, Flehr Hohbach Test Albritton & Herbert, December 4, 2001: US06327410 (232 worldwide citation)


A microsphere-based analytic chemistry system and method for making the same is disclosed in which microspheres or particles carrying bioactive agents may be combined randomly or in ordered fashion and dispersed on a substrate to form an array while maintaining the ability to identify the location o ...


43
Kam S Law, Cissy Leung, Ching C Tang, Kenneth S Collins, Mei Chang, Jerry Y K Wong, David Nin Kou Wang: Reactor chamber self-cleaning process. Applied Materials, Philip A Dalton, October 2, 1990: US04960488 (232 worldwide citation)


A process for cleaning a reactor chamber both locally adjacent the RF electrodes and also throughout the chamber and the exhaust system to the including components such as the throttle valve. Preferably, a two-step continuous etch sequence is used in which the first step uses relatively high pressur ...


44
Louis Terminiello, Jack L Aronowitz: Test strip and fixture. Technimed Corporation, John H Faro, December 13, 1988: US04790979 (225 worldwide citation)


A test strip is disclosed which provides for transport and separation of heterogenous fluid samples. This test strip can be used for analysis of whole blood by reflectance measurement. This test strip, which can be especially adapted for use in a disposable blood sampling fixture, comprises two func ...


45
Douglas W Walker, Frank M Ordaz, M Terry Olson: Cordless surgical handpiece with disposable battery; and method. Medtronic, Gene W Arant, Larry D Baker, October 3, 2000: US06126670 (224 worldwide citation)


A surgical procedure is disclosed utilizing a cordless surgical handpiece powered from a sterile battery pack that contains a battery in condition for immediate use without further charging or sterilization. The battery chemistry is based upon lithium/manganese dioxide, and the battery after a singl ...


46
Christopher P Holmes: Immobilized molecular synthesis of systematically substituted compounds. Affymax Technologies, Townsend and Townsend and Crew, June 18, 1996: US05527681 (222 worldwide citation)


A synthetic strategy for the creation of large scale chemical diversity is claimed. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis of an array of polymers that are based on a target polym ...


47
Yan Ye, Pavel Ionov, Allen Zhao, Peter Chang Lin Hsieh, Diana Xiaobing Ma, Chun Yan, Jie Yuan: Method of etching patterned layers useful as masking during subsequent etching or for damascene structures. Applied Materials, Shirley L Church, June 27, 2000: US06080529 (217 worldwide citation)


A first embodiment of the present invention pertains to a method of patterning a semiconductor device conductive feature while permitting easy removal of any residual masking layer which remains after completion of the etching process. A multi-layered masking structure is used which includes a layer ...


48
Michael P Nova, Hanan Potash: Matrices with memories. Discovery Partners International, Kilpatrick Stockton, January 22, 2002: US06340588 (216 worldwide citation)


Combinations, called matrices with memories, of matrix materials that are encoded with an optically readable code are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The matrix material ...


49
David R Walt, Todd A Dickinson: Self-encoding fiber optic sensor. Trustees of Tufts College, Dorsey & Whitney, Robin M Silva, October 3, 2006: US07115884 (200 worldwide citation)


Self-encoding microspheres having distinct characteristic optical response signatures to specific target analytes may be mixed together while the ability is retained to identify the sensor type and location of each sensor in a random dispersion of large numbers of such sensors in a sensor array usin ...


50
R Fabian Pease, Glenn McGall, Martin J Goldberg, Richard P Rava, Stephen P A Fodor, Virginia Goss, Lubert Stryer, James L Winkler: Printing molecular library arrays using deprotection agents solely in the vapor phase. Affymetrix, Townsend & Townsend & Crew, February 4, 1997: US05599695 (193 worldwide citation)


A method and apparatus for selectively applying a print material onto a substrate for the synthesis of an array of oligonucleotides at selected regions of a substrate. The print material includes a barrier material, a monomer sequence, a nucleoside, a deprotection agent, a carrier material, among ot ...



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