1
Spanholtz Jan: Methods and means for stem cell proliferation and subsequent generation and expansion of progenitor cells, as well as production of effector cells as clinical therapeutics.. Ipd Therapeutics, Spanholtz Jan, VAN LOON C J J, April 5, 2007: WO/2007/037682 (4 worldwide citation)


The invention provides means and methods for stem cell proliferation and subsequent generation and expansion of progenitor cells. The invention in particular provides media and other culture conditions for the same. The cells are preferably used as effector cells as clinical therapeutics.


2
Spanholtz Jan: Methods and means for stem cell proliferation and subsequent generation and expansion of progenitor cells, as well as production of effector cells as clinical therapeutics. Ipd Therapeutics, Spanholtz Jan, HATZMANN MJ, October 2, 2008: WO/2008/118020 (4 worldwide citation)


The invention is related to methods for expanding and differentiating hemopoietic progenitor cells in a medium comprising a collection of cytokines, desulphated glycosaminoglycan and human serum. The invention further relates to a collection of cells obtainable by a method of the invention, use of t ...


3
Jwala Karnik, Clint Carnell, Jesse Rosen, John Allison: Methods and systems for treatment of spasticity. MYOSCIENCE, Kilpatrick Townsend and Stockton, June 6, 2017: US09668800


A system for alleviating spasticity of a skeletal muscle having an associated motor nerve. The system may include a needle probe having at least one needle. The at least one needle has a proximal end, a distal end, and a needle lumen therebetween. The needle is configured for insertion proximate to ...


4
Jason M Vaughn, Justin R Hughey, Tanesha Roberts, Tatyana Dyakonov, Sunil Agnihotri, Aqeel A Fatmi: Fumarate ester dosage forms. BANNER LIFE SCIENCES, Brinks Gilson & Lione, May 2, 2017: US09636319


Described herein are pharmaceutical compositions comprising fumarate esters, methods for making the same, and methods for treating subjects in need thereof. In particular, oral controlled release pharmaceutical compositions comprising fumarate esters suspended in liquid matrices are described. One e ...


5
Kevin G Connors, Hung Cao: Delivery system for inflatable implant. AttenueX Technologies, Knobbe Martens Olson & Bear, April 11, 2017: US09615911


An implant delivery system can be used to deliver an implant into a body. The implant delivery system can include an inflation tube and a tubular member surrounding the inflation tube. The inflation tube can be used to provide an inflation medium to the implant. The tubular member can have a distal ...


6
Jason M Vaughn, Justin R Hughey, Tanesha Roberts, Tatyana Dyakonov, Sunil Agnihotri, Aqeel A Fatmi: Fumarate ester dosage forms. BANNER LIFE SCIENCES, Brinks Gilson & Lione, February 14, 2017: US09566259


Described herein are pharmaceutical compositions comprising fumarate esters, methods for making the same, and methods for treating subjects in need thereof. In particular, oral controlled release pharmaceutical compositions comprising fumarate esters suspended in liquid matrices are described. One e ...


7
Jason M Vaughn, Justin R Hughey, Tanesha Roberts, Tatyana Dyakonov, Sunil Agnihotri, Aqeel A Fatmi: Fumarate ester dosage forms. BANNER LIFE SCIENCES, Brinks Gilson & Lione, May 2, 2017: US09636318


Described herein are pharmaceutical compositions comprising fumarate esters, methods for making the same, and methods for treating subjects in need thereof. In particular, oral controlled release pharmaceutical compositions comprising fumarate esters suspended in liquid matrices are described. One e ...


8
Jonathan Barasch, Andong Qiu: Mutant NGAL proteins and uses thereof. THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, Wilmer Cutler Pickering Hale and Dorr, April 18, 2017: US09624281


In one aspect the present invention is directed to mutant NGAL proteins that have the ability to bind to siderophores, such as enterochelin, and to chelate and transport iron, and that are excreted in the urine. Such NGAL mutants, and complexes thereof with siderophores, can be used to clear excess ...


9
Marino Nebuloni, Patrizia Colombo: Eutectic formulations of cyclobenzaprine hydrochloride and amitriptyline hydrochloride. TONIX PHARMA HOLDINGS, Ropes & Gray, May 2, 2017: US09636408


The present invention relates to pharmaceutical compositions and methods of manufacturing the same, comprising a eutectic of Cyclobenzaprine HCl and mannitol or Amitriptyline HCl and mannitol.


10
Jan Steyaert, Toon Laeremans, Els Pardon: Chimeric polypeptides comprising G protein-coupled receptors and VHH antibodies. VIB VZW, Vrije Universiteit Brussel, TraskBritt P C, March 14, 2017: US09593157


Described are polypeptides and their use for screening and drug discovery. More specifically, the disclosure provides chimeric polypeptides comprising a membrane protein, in particular a GPCR, fused to a binding domain, wherein the binding domain is directed against and/or specifically binds to the ...



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