1
Gale Eugene Smith, Franklin Volvovitz, Bethanie Eident Wilkinson, Craig Stanway Hackett: Method for producing influenza hemagglutinin multivalent vaccines using baculovirus. MG PMC, Thomas J Kowalski, Curtis Morris & Safford PC, June 9, 1998: US05762939 (82 worldwide citation)


A method of preparing a recombinant influenza vaccine using DNA technology is provided. The resulting vaccine is a trivalent influenza vaccine based on a mixture of recombinant hemagglutinin antigens cloned from influenza viruses having epidemic potential. The recombinant hemagglutinin antigens are ...


2
Robert G Webster, Nicolai V Kaverin: Influenza virus replicated in mammalian cell culture and vaccine production. St Jude Children&apos s Research Hospital, Sterne Kessler Goldstein & Fox P L L C, February 5, 2002: US06344354 (40 worldwide citation)


The invention provides replication of high growth influenza virus strains, derived from clinical isolates, in cultured mammalian cells by infecting the mammalian cells with the high growth strains to obtain infected cells, and culturing the cells while maintaining a trypsin concentration range of 0. ...


3
Audino Podda, Nicola Groth, Michele Pellegrini: Adjuvanted influenza vaccines for pediatric use. Novartis, Helen Lee, Otis Littlefield, August 13, 2013: US08506966 (36 worldwide citation)


An influenza vaccine adjuvanted with a sub-micron oil-in-water emulsion elicits significantly higher immune responses in human pediatric populations. Compared to an existing unadjuvanted pediatric influenza vaccine, the adjuvanted vaccines provided herein can induce in children a longer persistence ...


4
Philippe Adamowicz, Ludwig Muller: Process for obtaining lipid envelope virus sub-units, notably antigens for use as vaccines, the products obtained and their applications. Institut Pasteur, Frost & Jacobs, June 11, 1985: US04522809 (28 worldwide citation)


A process is disclosed for producing virus sub-units with lipid envelopes, comprising, in a neutral or basic pH, dissolving a lower halogenated hydrocarbon, at a concentration equivalent to or approximating its limit of solubility, in an aqueous virus suspension, thereafter contacting, with stirring ...


5
Gale E Smith, Franklin Volvovitz, Bethanie E Wilkinson, Andrei I Voznesensky, Craig S Hackett: Method for producing influenza hemagglutinin multivalent vaccines. Protein Sciences Corporation, Thomas J Kowalski, Frommer Lawrence & Haug, June 12, 2001: US06245532 (24 worldwide citation)


A method of preparing a recombinant influenza vaccine using DNA technology is provided. The resulting vaccine is a multivalent, preferably trivalent, influenza vaccine based on a mixture of recombinant hemagglutinin antigens cloned from influenza viruses having epidemic potential. The recombinant he ...


6
Richard Schwartz, John Michael Berry, Weidong Cui: Methods of producing influenza vaccine compositions. MedImmune Vaccines, August 28, 2007: US07262045 (19 worldwide citation)


Methods and compositions for the optimization of production of influenza viruses suitable as influenza vaccines are provided.


7
Francis Robert Cano: Process for the purification of influenza virus vaccine. American Cyanamid Company, Neal O Willmann, December 28, 1976: US04000257 (17 worldwide citation)


A process for producing high potency influenza vaccines with low pyrogenicity and low endotoxicity involves treating concentrated allantoic fluid (CAF) containing an attenuated virus sequentially with butyl acetate and ethyl acetate followed by flash evaporation.


8
Robert G Webster, Nicolai V Kaverin: Influenza virus replicated in mammalian cell culture and vaccine production. St Jude Children s Research Hospital, Sterne Kessler Goldstein & Fox P L L C, October 20, 1998: US05824536 (17 worldwide citation)


The invention provides replication of high growth influenza virus strains, derived from clinical isolates, in cultured mammalian cells by infecting the mammalian cells with the high growth strains to obtain infected cells, and culturing the cells while maintaining a trypsin concentration range of 0. ...


9
Robert Webster: DNA transcription unit vaccines that protect against avian influenza viruses and methods of use thereof. St Jude Children s Research Hospital, Klauber & Jackson, June 29, 1999: US05916879 (17 worldwide citation)


The present invention describes a reliably protective avian vaccine that contains a DNA transcription unit comprising a nucleic acid that encodes a viral protein. This effective and reliable avian vaccine significantly improves upon that which heretofore has been disclosed. The present invention dem ...


10
Pau Maria Grazia, Uytdehaag Alphonsus Gerardus C, Schouten Govert Johan: Production of vaccines. Crucell Holland, June 20, 2001: EP1108787-A2 (15 worldwide citation)


Novel means and methods are provided for the production of mammalian viruses, comprising infecting a culture of immortalized human cells with the virus, incubating the culture infected with virus to propagate the virus under conditions that permit growth of the virus, and to form a virus-containing ...



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