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Antonin Holy, Erik Desire Alice De Clercq: N.sup.6 - substituted nucleotide analagues and their use. Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v z w, Max D Hensley, November 2, 1999: US05977061 (99 worldwide citation)


Novel PMP, PME and HPMP and related compounds containing N-6 substituted 2,6-diaminopurine and adenine bases are provided. These compounds are useful in a variety of utilities, including as intermediates in the preparation of flame retardants, diagnostic reagents and therapeutics, including antivira ...


2
John E Starrett Jr, Muzammil M Mansuri, John C Martin, David R Tortolani, Joanne J Bronson: Prodrugs of phosphonates. Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v z w, Max D Hensley, September 2, 1997: US05663159 (94 worldwide citation)


There are disclosed novel oral prodrugs of phosphonate nucleotide analogs which are hydrolyzable under physiological conditions to yield compounds which are useful as antiviral agents, especially as agents effective against RNA and DNA viruses. They may also find use as antitumor agents.


3
John E Starrett Jr, Muzammil M Mansuri, John C Martin, David R Tortolani, Joanne J Bronson: Prodrugs of phosphonates. Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v z w, Max D Hensley, August 11, 1998: US05792756 (74 worldwide citation)


There are disclosed novel oral prodrugs of phosphonate nucleotide analogs which are hydrolyzable under physiological conditions to yield compounds which are useful as antiviral agents, especially as agents effective against RNA and DNA viruses. They may also find use as antitumor agents.


4
Antonin Holy, Hana Dvorakova, Erik Desire Alice DeClercq, Jan Marie Rene Balzarini: Antiretroviral enantiomeric nucleotide analogs. Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v z w, Max D Hensley, May 2, 2000: US06057305 (67 worldwide citation)


Resolved enantiomers of the formula ##STR1## wherein B is a purine or pyrimidine base or aza and/or deaza analogs thereof are useful in antiviral pharmaceutical compositions to treat retroviral infections.


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Duan Youlu, Jin Shanrong, Huang Tingchun, Sun Jin, Yu Xinying: Fluoropolymer alloys. Shanghai Institute of Organic Chemistry Academia Sinica, Ladas & Parry, June 7, 1988: US04749752 (53 worldwide citation)


Fluoropolymer alloys made of melt fabricatable extra-high-molecular weight fluorinated ethylene-propylene copolymer (EHMW-FEP) and one or more other polymers. In fluoropolymer alloys made of EHMW-FEP and polytetrafluoroethylene, the weight percentage of the former is 0.1-99.9% and the latter is 99.9 ...


7
Hajek Miroslav, Matulova Nadezda, Votruba Ivan, Holy Antonin, Tloustova Eva: Use of compounds to enhance processivity of telomerase. Institute Of Organic Chemistry And Biochemistry Ofthe Academy Of Sciences Of The Czech Republic, Hajek Miroslav, Matulova Nadezda, Votruba Ivan, Holy Antonin, Tloustova Eva, GABRIELOVA Marta, November 2, 2006: WO/2006/114064 (49 worldwide citation)


The invention provides the use of acyclic nucleoside phosphonates and their derivatives for the preparation of a medicament for enhancing the processivity of a telomerase increasing the number of mitotic cycles and mitotic cell division.


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Hajek Miroslav, Matulova Nadezda, Votruba Ivan, Holy Antonin, Tloustova Eva: Use of compounds to inhibit neoplasia. Institute Of Organic Chemistry And Biochemistry A Cademy Of Sciences Of The Czech Republic, Hajek Miroslav, Matulova Nadezda, Votruba Ivan, Holy Antonin, Tloustova Eva, GABRIELOVA Marta, November 2, 2006: WO/2006/114065 (48 worldwide citation)


The invention provides the use of acyclic nucleoside phosphonates and their derivatives for the manufacture of a medicament for inhibiting an enzyme that causes neoplasia in an animal (e.g. a human) and enhancing the processivity of a telomerase.


9
Minkkinen Ari, Alario Fabio: A new process for the production of para-xylene. Inst Francais Du Petrole, March 26, 1999: FR2768724-A1 (43 worldwide citation)


A method for the separation of para-xylene from an 8C aromatic charge by means of an adsorption stage, a liquid phase isomerization stage without addition of hydrogen and a vapor phase isomerization of ethylbenzene.- DETAILED DESCRIPTION - The initial charge contains ortho, meta and para-xylenes and ...


10
Zupancic Silvo, Skrabanja Vida: Process for preparation of o-desmethylvenlafaxine and its analogue. Krka D D Novo Mesto, December 26, 2007: EP1870395-A1 (37 worldwide citation)


The present invention belongs to the field of organic chemistry and refers to a process for the preparation of O -desmethylvenlafaxine (1-[2-Dimethylamino)-1-(4-hydroxyphenyl)ethyl]cyclohexanol) and its analogues. The invention also relates to a catalytic hydrogenation of cyano-group of the substitu ...



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